Protein Structures

The following table showcases the protein structures discovered and characterized by the CQMED team in collaboration with our partners. These structures have provided valuable insights into kinase biology and have the potential to inform the development of new therapeutic strategies.

Year	PDB Code	Description
2024	8V42	Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400
2022	7S6U	Leishmania infantum Glycogen Synthase Kinase 3 beta bound to AZD5438
2022	7S6V	Leishmania infantum Glycogen Synthase Kinase 3 beta bound to CGP60474
2022	7LQD	Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor
2021	7NAA	Crystal structure of Mycobacterium tuberculosis H37Rv PknF kinase domain
2021	6VXU	Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471
2020	6W3Z	Crystal Structure of Brugia malayi Deoxyhypusine synthase (DHPS)
2020	6VXR	Structure of Maternal embryonic leucine zipper kinase bound to LDSM276
2020	6VXH	Structure of ABCG2 bound to imatinib
2019	6PJJ	Human PRPF4B bound to benzothiophene inhibitor 224
2019	6PK6	Human PRPF4B bound to benzothiophene inhibitor 329
2019	6PCW	Human PIM1 bound to benzothiophene inhibitor 213
2019	6PDI	Human PIM1 bound to benzothiophene inhibitor 224
2019	6PDN	Human PIM1 bound to benzothiophene inhibitor 292
2019	6PDO	Human PIM1 bound to benzothiophene inhibitor 354
2019	6PDP	Human PIM1 bound to benzothiophene inhibitor 379
2019	6NPN	Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor
2019	6NCG	Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor
2018	6EAS	Co-crystal of pseudokinase DRIK1 (drought responsive inactive kinase 1) bound to ENMD-2076
2018	5WAX	Crystal Structure of Sugarcane SAPK10 (serine/threonine-protein kinase 10)
2018	6DD4	Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropyl-dihydropteridine inhibitor
2018	6CTH	Crystal Structure of Pathogenesis-related Protein 1G (PR-1G) Kinase Domain from Cacao
2018	6CNX	Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor
2018	6CPY	Structure of apo GRMZM2G135359 pseudokinase
2018	6CSW	Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor
2018	6CNH	Human PRPF4B in complex with Rebastinib
2018	6CMM	Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor
2018	6CQH	Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor
2018	6CQH	Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor.
2018	6CCF	Crystal Structure of the Human CAMKK1A in complex with Hesperadin.
2018	6CD6	Crystal Structure of the Human CAMKK1A in complex with GSK650394.
2018	6CFM	Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor.
2017	6BTW	Crystal Structure of the Human vaccinia-related kinase bound to a phenyl-pteridinone inhibitor.
2017	6BU6	Crystal Structure of the Human vaccinia-related kinase bound to a bis-difluorophenol-aminopyridine inhibitor.
2017	6BQL	Crystal Structure of the Human CAMKK2B in complex with TAE-226.
2017	6BQP	Crystal Structure of the Human CAMKK2B in complex with Crenolanib.
2017	6BQQ	Crystal Structure of the Human CAMKK2B in complex with BI2526.
2017	6BRC	Crystal Structure of the Human CAMKK2B in complex with AP26113-analog (ALK-IN-1).
2017	6BRU	Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor.
2017	6BP0	Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor.
2017	6BKU	Crystal Structure of the Human CAMKK2B bound to GSK650394.
2017	6BLE	Crystal Structure of the Human CAMKK2B in complex with CP673451.
2017	5VT1	Crystal Structure of the Human CAMKK2B bound to a thiadiazinone benzamide inhibitor.