The following table showcases the protein structures discovered and characterized by the CQMED team in collaboration with our partners. These structures have provided valuable insights into kinase biology and have the potential to inform the development of new therapeutic strategies.
| Year | PDB Code | Description |
|---|---|---|
| 2024 | 8V42 | Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to ACH000400 |
| 2022 | 7S6U | Leishmania infantum Glycogen Synthase Kinase 3 beta bound to AZD5438 |
| 2022 | 7S6V | Leishmania infantum Glycogen Synthase Kinase 3 beta bound to CGP60474 |
| 2022 | 7LQD | Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor |
| 2021 | 7NAA | Crystal structure of Mycobacterium tuberculosis H37Rv PknF kinase domain |
| 2021 | 6VXU | Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471 |
| 2020 | 6W3Z | Crystal Structure of Brugia malayi Deoxyhypusine synthase (DHPS) |
| 2020 | 6VXR | Structure of Maternal embryonic leucine zipper kinase bound to LDSM276 |
| 2020 | 6VXH | Structure of ABCG2 bound to imatinib |
| 2019 | 6PJJ | Human PRPF4B bound to benzothiophene inhibitor 224 |
| 2019 | 6PK6 | Human PRPF4B bound to benzothiophene inhibitor 329 |
| 2019 | 6PCW | Human PIM1 bound to benzothiophene inhibitor 213 |
| 2019 | 6PDI | Human PIM1 bound to benzothiophene inhibitor 224 |
| 2019 | 6PDN | Human PIM1 bound to benzothiophene inhibitor 292 |
| 2019 | 6PDO | Human PIM1 bound to benzothiophene inhibitor 354 |
| 2019 | 6PDP | Human PIM1 bound to benzothiophene inhibitor 379 |
| 2019 | 6NPN | Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor |
| 2019 | 6NCG | Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor |
| 2018 | 6EAS | Co-crystal of pseudokinase DRIK1 (drought responsive inactive kinase 1) bound to ENMD-2076 |
| 2018 | 5WAX | Crystal Structure of Sugarcane SAPK10 (serine/threonine-protein kinase 10) |
| 2018 | 6DD4 | Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropyl-dihydropteridine inhibitor |
| 2018 | 6CTH | Crystal Structure of Pathogenesis-related Protein 1G (PR-1G) Kinase Domain from Cacao |
| 2018 | 6CNX | Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor |
| 2018 | 6CPY | Structure of apo GRMZM2G135359 pseudokinase |
| 2018 | 6CSW | Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor |
| 2018 | 6CNH | Human PRPF4B in complex with Rebastinib |
| 2018 | 6CMM | Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor |
| 2018 | 6CQH | Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor |
| 2018 | 6CQH | Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor. |
| 2018 | 6CCF | Crystal Structure of the Human CAMKK1A in complex with Hesperadin. |
| 2018 | 6CD6 | Crystal Structure of the Human CAMKK1A in complex with GSK650394. |
| 2018 | 6CFM | Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor. |
| 2017 | 6BTW | Crystal Structure of the Human vaccinia-related kinase bound to a phenyl-pteridinone inhibitor. |
| 2017 | 6BU6 | Crystal Structure of the Human vaccinia-related kinase bound to a bis-difluorophenol-aminopyridine inhibitor. |
| 2017 | 6BQL | Crystal Structure of the Human CAMKK2B in complex with TAE-226. |
| 2017 | 6BQP | Crystal Structure of the Human CAMKK2B in complex with Crenolanib. |
| 2017 | 6BQQ | Crystal Structure of the Human CAMKK2B in complex with BI2526. |
| 2017 | 6BRC | Crystal Structure of the Human CAMKK2B in complex with AP26113-analog (ALK-IN-1). |
| 2017 | 6BRU | Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor. |
| 2017 | 6BP0 | Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor. |
| 2017 | 6BKU | Crystal Structure of the Human CAMKK2B bound to GSK650394. |
| 2017 | 6BLE | Crystal Structure of the Human CAMKK2B in complex with CP673451. |
| 2017 | 5VT1 | Crystal Structure of the Human CAMKK2B bound to a thiadiazinone benzamide inhibitor. |